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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
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Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

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Related Experiment Video

Updated: May 22, 2026

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

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Published on: January 2, 2012

Functional graph alterations in schizophrenia: a result from a global anatomic decoupling?

J Cabral1, M L Kringelbach, G Deco

  • 1Theoretical and Computational Neuroscience Group, Center for Brain and Cognition, Universitat Pompeu Fabra, Barcelona, Spain. joana.cabral@upf.edu

Pharmacopsychiatry
|May 9, 2012
PubMed
Summary

Schizophrenia alters brain functional networks, showing reduced small-worldness and increased hierarchy. A new model suggests these changes stem from decreased brain-wide coupling strength, impacting cognitive performance.

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Area of Science:

  • Neuroscience
  • Graph Theory
  • Psychiatry

Background:

  • The brain's resting-state functional networks exhibit slow hemodynamic fluctuations correlated across regions.
  • Previous studies show altered graph properties in schizophrenia, including reduced small-worldness and increased hierarchy.

Purpose of the Study:

  • To investigate if a brain-wide coupling deficit underlies the observed network reorganization in schizophrenia.
  • To model resting-state activity and manipulate coupling strength to understand network alterations.

Main Methods:

  • Utilized a computational model of resting-state brain activity with adjustable coupling strength.
  • Analyzed simulated functional graphs using graph theory metrics.
  • Compared simulated graph properties to those observed in schizophrenia patients and healthy controls.

Main Results:

  • Simulated graphs mirrored healthy brain network properties within a specific coupling range.
  • Decreasing coupling strength induced topological reorganization similar to schizophrenia network alterations.
  • Most altered graph parameters correlated with patients' cognitive performance.

Conclusions:

  • Complex functional graph alterations in schizophrenia can be explained by a decrease in structural coupling strength.
  • Reduced white matter density in schizophrenia supports the hypothesis of impaired structural coupling.
  • This finding offers a potential mechanistic link between brain connectivity and cognitive deficits in schizophrenia.