Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions with oral contraceptives.

K Fotherby1

  • 1Department of Steroid Biochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.

American Journal of Obstetrics and Gynecology
|December 1, 1990
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Partial pituitary ablation with implants of gold-198 and yttrium-90 for Cushing's syndrome with associated adrenal hyperplasia.

British medical journal·2010
Same author

Can a change in screening and prescribing practice reduce the risk of venous thromboembolism in women taking the combined oral contraceptive pill?

The British journal of family planning·1999
Same author

Recommendations for clinical practice: actinomyces like organisms and intrauterine contraceptives. The Clinical and Scientific Committee.

The British journal of family planning·1999
Same author

Metabolic interrelationships, cardiovascular disease, and sex steroids.

Contraception·1998
Same author

Bioavailability of orally administered sex steroids used in oral contraception and hormone replacement therapy.

Contraception·1996
Same author

Guidelines for prescribing combined oral contraceptives.

BMJ (Clinical research ed.)·1996

Oral contraceptive drug interactions can occur through absorption, protein binding, or liver metabolism. Some medications may reduce oral contraceptive effectiveness, though serious interactions remain rare.

Area of Science:

  • Pharmacology
  • Drug Interactions

Background:

  • Oral contraceptives (OCs) are widely used, and understanding their interactions is crucial for patient safety.
  • Pharmacokinetic and pharmacodynamic interactions can influence the efficacy and safety of OCs.

Purpose of the Study:

  • To review the various factors interacting with the pharmacologic activity of oral contraceptives.
  • To highlight potential pharmacokinetic and pharmacodynamic interactions affecting oral contraceptive efficacy.

Main Methods:

  • Literature review of pharmacokinetic and pharmacodynamic interactions with oral contraceptives.
  • Analysis of factors affecting oral contraceptive metabolism, including drug-drug and drug-nutrient interactions.

Main Results:

  • Interactions can occur during absorption, protein binding, and hepatic metabolism, primarily involving the cytochrome P450 system.
Keywords:
BiologyContraceptionContraception Failure--determinantsContraceptive Methods--pharmacodynamicsContraceptive UsageDrug Interactions--determinantsDrugsEndocrine SystemEstrogens--pharmacodynamicsFamily PlanningHealthHepatic EffectsHormonesMetabolic EffectsNutritionOral Contraceptives--pharmacodynamicsPhysiologyProgestational HormonesProgesterone--pharmacodynamicsSteroid Metabolic EffectsTreatment

Related Experiment Videos

  • Certain anticonvulsant, antibiotic, and antibacterial drugs may decrease oral contraceptive efficacy.
  • Serious interactions are infrequent, possibly due to significant inter-individual variability in OC pharmacokinetics.

    • Conclusions:

    • Understanding drug interactions is essential for optimizing oral contraceptive therapy.
    • While serious interactions are uncommon, awareness of potential efficacy reductions is important for healthcare providers and patients.