Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Introduction to the Integumentary System01:25

Introduction to the Integumentary System

The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.

Science immunology·2026
Same author

Analysis Of Salivary Herpesviruses Reveals Associations Between HHV-6 And Long COVID Severity.

medRxiv : the preprint server for health sciences·2026
Same author

A causal link between autoantibodies and neurological symptoms in long COVID.

Cell·2026
Same author

Freedom of scientific inquiry: reclaiming space for controversy.

Nature reviews. Immunology·2026
Same author

Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice.

bioRxiv : the preprint server for biology·2026
Same author

Ocular Symptoms in Long COVID: A Cross-Sectional Study.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Galvanin: a molecular compass for bioelectric navigation.

Cell research·2026
Same journal

Why microglial repair programs fade.

Cell research·2026
Same journal

Atypical signaling, ligand recognition and selective agonist discovery of complement receptor C5aR2.

Cell research·2026
Same journal

One drug, five targets.

Cell research·2026
Same journal

Smooth emotional response: amygdalar neurovascular coupling drives stress encoding.

Cell research·2026
Same journal

Liquid surrogates of spatial tumor ecosystems.

Cell research·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

Skin T(RM) mediates distributed border patrol.

Haina Shin1, Akiko Iwasaki

  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Cell Research
|May 9, 2012
PubMed
Summary
This summary is machine-generated.

Tissue-resident memory T cells (TRM) offer enhanced immunity at their resident tissue. Jiang et al. show TRM migrate within skin and protect against re-infection, even in previously uninfected areas.

More Related Videos

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

Related Experiment Videos

Last Updated: May 22, 2026

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

Area of Science:

  • Immunology
  • Cell Biology
  • Infectious Disease

Background:

  • Tissue-resident memory T cells (TRM) are crucial for localized immune surveillance.
  • Understanding TRM migration is key to optimizing protective immunity.
  • Previous studies focused on TRM function within their initial site of residence.

Purpose of the Study:

  • To investigate the migration patterns of TRM within skin tissue.
  • To determine if TRM can provide protection against re-infection in naive skin sites.
  • To elucidate the role of TRM in adaptive immunity beyond their site of initial encounter.

Main Methods:

  • Utilized mouse models to track TRM behavior in vivo.
  • Employed advanced imaging techniques to visualize cell migration.
  • Assessed immune protection following secondary challenge in different skin locations.

Main Results:

  • TRM were observed to migrate actively within both infected and uninfected skin compartments.
  • TRM demonstrated protective capabilities against pathogen re-challenge in previously uninfected skin.
  • Migration of TRM facilitated a rapid and effective secondary immune response.

Conclusions:

  • TRM possess migratory potential within the skin, extending their protective reach.
  • This migratory capacity enhances the overall efficacy of tissue-resident memory immunity.
  • TRM represent a dynamic cellular population critical for sustained tissue protection.