Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Accessory Structures of the Skin: Nails

Accessory Structures of the Skin: Nails

Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...

Pedigree Analysis

Pedigree Analysis

Karyotyping

Karyotyping

Pleiotropy

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pirfenidone-Induced Lichen Planus Pigmentosus in a Patient with Idiopathic Pulmonary Fibrosis.

Indian dermatology online journal·2026

Same author

The impact of training front-line health care workers in improving the yield of scabies diagnosis among children under five in a rural community of West Bengal.

PLoS neglected tropical diseases·2025

Same author

Spectrum of sensitive skin in India: a collaborative expert position statement.

Frontiers in medicine·2025

Same author

Correlation of Antimuscarinic Acetylcholine Receptor Antibody Titers With Pemphigus Disease Activity at Baseline and Following Phase I Pulse Therapy.

Cureus·2025

Same author

Loss-of-function variants in DUSP1 encoding dual specificity phosphatase 1 cause palmoplantar keratoderma.

The British journal of dermatology·2025

Same author

Amniotic membrane grafting for acute ocular involvement in Stevens-Johnson syndrome: Review of perioperative considerations, surgical techniques, and outcomes.

Indian journal of ophthalmology·2025

Search research articles

Related Experiment Video

Updated: May 22, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Nails: diagnostic clue to genodermatoses.

Arun C Inamadar¹, Aparna Palit

¹Department of Dermatology, Venereology and Leprosy, Sri B.M. Patil Medical College, Hospital and Research Center, BLDE University, Bijapur, Karnataka, India. aruninamadar@rediffmail.com

Indian Journal of Dermatology, Venereology and Leprology

|May 9, 2012

Summary

This summary is machine-generated.

Nail changes can indicate underlying systemic diseases, particularly genodermatoses. Examining nail alterations provides crucial diagnostic clues for these complex genetic skin disorders.

More Related Videos

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Published on: February 28, 2025

Related Experiment Videos

Last Updated: May 22, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Published on: February 28, 2025

Area of Science:

Dermatology
Genetics
Internal Medicine

Background:

Nails are skin appendages with primary mechanical functions.
Nail morphology (shape, size, color, texture) can reveal systemic health conditions.
Genodermatoses are genetic disorders affecting multiple systems, often including the skin and nails.

Purpose of the Study:

To explore the diagnostic significance of nail changes in genodermatoses.
To highlight how nail findings can serve as early indicators for genetic skin disorders.
To discuss specific nail abnormalities associated with various genodermatoses.

Main Methods:

Review of clinical literature on genodermatoses and nail manifestations.
Analysis of case studies linking nail findings to specific genetic diagnoses.
Compilation of diagnostic clues derived from nail examination.

Main Results:

Nail abnormalities are common in many genodermatoses.
Specific nail changes correlate with particular genetic syndromes.
Nail examination can be a non-invasive diagnostic tool for genodermatoses.

Conclusions:

Nail assessment is a valuable component in diagnosing genodermatoses.
Recognizing nail alterations can lead to earlier and more accurate diagnoses.
Further research into nail-pathology correlations can enhance diagnostic strategies for genetic disorders.