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Updated: May 22, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
Published on: March 31, 2016
[Comatose state--think different]
Abstract:
We report the case of a 76-year old woman, who presented with signs of a meningoencephalitis. The result of lumbar puncture showed a mononuclear pleocytosis. Empirical antimicrobial treatment was promptly initiated. Nevertheless a comatose state complicated the clinical course. The diagnosis of neuroborreliosis was made serologically and by molecular biology. Under adequate therapy with intravenous ceftriaxone the patient showed a slow but full recovery. This case illustrates that potentially reversible diseases need very careful decision making regarding therapeutic activities and that neuroborreliosis is a potentially reversible cause of severe neurologic impairment.
Insights
A severe neurological condition, neuroborreliosis, can be reversed with prompt treatment. This case highlights the importance of accurate diagnosis for potentially reversible neurological impairments.
Area of Science:
- Neurology
- Infectious Diseases
- Medical Case Reports
Background:
- Meningoencephalitis presents with inflammation of the brain and meninges.
- Early diagnosis and treatment are crucial for managing neurological infections.
Observation:
- A 76-year-old woman presented with meningoencephalitis and mononuclear pleocytosis.
- Her condition worsened to a comatose state despite empirical antimicrobial treatment.
Findings:
- Neuroborreliosis was confirmed serologically and via molecular biology.
- Intravenous ceftriaxone therapy led to a slow but complete recovery.
Implications:
- This case underscores the need for careful decision-making in treating potentially reversible neurological diseases.
- Neuroborreliosis is identified as a treatable cause of severe neurological impairment.
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