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[Polymyalgia induced by topical minoxidil].

R Colamarino¹, J J Dubost, P Brun

¹Unité d'Immunologie Clinique, Service de Rhumatologie, Hôpital Saint-Jacques, Clermont-Ferrand.

Annales De Medecine Interne

|January 1, 1990

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Topical minoxidil, a baldness treatment, may cause rare polymyalgia syndrome. Symptoms like fatigue and pain resolved after discontinuing the medication.

Area of Science:

Dermatology
Rheumatology
Ophthalmology

Background:

Topical minoxidil has been available for treating baldness since 1987.
Systemic side effects are considered rare.

Observation:

Four healthy males using topical minoxidil developed polymyalgia syndrome.
Symptoms included fatigue, weight loss, and severe shoulder/pelvic girdle pain.
Two patients showed tritanomaly during color vision testing.

Findings:

Three patients experienced transient elevations in liver enzymes.
All reported symptoms resolved upon minoxidil withdrawal.
Positive rechallenge occurred in two patients, confirming causality.

Implications:

Related Experiment Videos

This study reports a novel side effect of topical minoxidil: polymyalgia syndrome.
The findings suggest a potential link between topical minoxidil and connective tissue-like symptoms.
Further research is needed to elucidate the mechanism behind these adverse effects.