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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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CD161-expressing human T cells.

Joannah R Fergusson1, Vicki M Fleming, Paul Klenerman

  • 1Sir William Dunn School of Pathology, University of Oxford Oxford, UK. joannah.fergusson@ path.ox.ac.uk

Frontiers in Immunology
|May 9, 2012
PubMed
Summary
This summary is machine-generated.

Natural Killer receptor CD161 is found on memory T cells (CD4+ and CD8+). These CD161+ T cells may be linked to interleukin-17 secretion and play roles in human diseases.

Keywords:
CD161NK cellsNK-T cellsNKRP1T cellsT helper 17 cellsinterleukin-17

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Natural Killer (NK) cell receptor CD161 expression is identified on a subset of T cells.
  • In adults, CD161 expression on T cells is limited to those with a memory phenotype.
  • CD161 expression on T cells has been associated with interleukin-17 (IL-17) secretion, suggesting a type 17 phenotype.

Purpose of the Study:

  • To investigate the distinct properties of CD161+ T cell populations.
  • To determine the origin of CD161+ T cells.
  • To elucidate the significance of CD161 expression as a marker or functional regulator in human diseases.

Main Methods:

  • Flow cytometry to identify and quantify CD161+ T cells.
  • Analysis of cytokine profiles, including IL-17, in CD161+ T cell subsets.
  • Investigation of T cell populations in various human disease contexts.

Main Results:

  • CD161 is expressed on both CD4+ and CD8+ T cells with a memory phenotype in adult circulation.
  • CD161 expression correlates with the production of IL-17, indicating a type 17 T helper cell phenotype.
  • Studies are ongoing to fully characterize the functional roles and disease implications of these cells.

Conclusions:

  • CD161+ T cells represent a distinct memory T cell subset.
  • These cells are potentially involved in inflammatory responses via IL-17 production.
  • Further research is needed to understand their precise role in human diseases.