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Updated: May 22, 2026
12:16
A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
Published on: October 16, 2018
Immunotherapy for B-cell lymphoma: current status and prospective advances
1Department of Clinical Microbiology and Immunology, Tel Aviv University Tel Aviv, Israel.
Frontiers in Immunology
|May 9, 2012
Summary
Immunotherapy offers new hope for non-Hodgkin
Area of Science:
- Hematology and Oncology
- Immunology
Background:
- Non-Hodgkin's lymphoma therapy has advanced, yet many patients remain incurable, necessitating novel treatments.
- Immunotherapy presents a promising avenue due to its target selectivity.
- Rituximab, an anti-CD20 monoclonal antibody, has significantly improved lymphoma care.
Purpose of the Study:
- To review current immunotherapy strategies for B-cell lymphoma.
- To discuss ongoing clinical trials and future directions in lymphoma immunotherapy.
Main Methods:
- Review of passive immunotherapy approaches, including enhanced rituximab efficacy and novel anti-CD20 antibodies.
- Exploration of active immunotherapy strategies such as vaccination and immune checkpoint blockade.
- Analysis of clinical trial data for various immunotherapy interventions.
Main Results:
- Passive immunotherapy includes improved rituximab, newer antibodies, antibody-drug conjugates, and bispecific antibodies.
- Active immunotherapy involves protein and cell-based vaccines, with early promising results from idiotype protein vaccines.
- Immune checkpoint blockade is being investigated to enhance active immunotherapy.
Conclusions:
- Immunotherapy, both passive and active, is a rapidly evolving field for B-cell lymphoma treatment.
- Ongoing research focuses on optimizing existing therapies and developing new strategies to improve patient outcomes and reduce relapse.
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