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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Allergic Reactions02:06

Allergic Reactions

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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.

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Related Experiment Video

Updated: May 22, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Mast cells and company.

Friederike Jönsson1, Marc Daëron

  • 1Institut Pasteur, Département d'Immunologie, Unité d'Allergologie Moléculaire et Cellulaire Paris, France.

Frontiers in Immunology
|May 9, 2012
PubMed
Summary

Allergy involves more than just IgE antibodies and mast cells. New research shows IgG antibodies and various myeloid cells also play key roles in allergic diseases, potentially changing treatments.

Area of Science:

  • Immunology
  • Allergy research
  • Cellular immunology

Background:

  • The traditional allergy model focuses on immunoglobulin E (IgE) antibodies and their high-affinity receptors (FcεRI) on mast cells and basophils.
  • This IgE-centric view, foundational to immediate hypersensitivity definitions, is increasingly recognized as overly simplistic.

Purpose of the Study:

  • To challenge the reductionist IgE/FcεRI/mast cell paradigm in allergy.
  • To highlight the broader cellular and molecular players involved in allergic responses.

Main Methods:

  • Review of recently accumulated scientific evidence.
  • Analysis of the roles of various antibody isotypes and cell types in allergic reactions.

Main Results:

Keywords:
Fc receptorsallergyanaphylaxisantibodiesbasophilsmast cellsneutrophils

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  • Evidence indicates that immunoglobulin G (IgG) antibodies are also significant in allergy.
  • Multiple Fc gamma receptors (FcγR) are implicated, not just FcεRI.
  • Beyond mast cells and basophils, neutrophils, monocytes, macrophages, and eosinophils are identified as crucial participants.

    • Conclusions:

    • The understanding of allergic diseases requires expanding beyond the classical IgE-mediated pathway.
    • Inclusion of IgG antibodies and diverse myeloid cells offers a more comprehensive view of allergy.
    • This broadened perspective may lead to novel therapeutic strategies for allergic conditions.