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Updated: May 22, 2026
05:14
Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
Published on: August 11, 2023
Is asthma related to choroidal neovascularization?
Yaoyao Sun1, Wenzhen Yu, Lvzhen Huang
1Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
Plos One
|May 9, 2012
Summary
Asthma may increase the risk of developing age-related macular degeneration (AMD). This study found asthma linked to choroidal neovascularization and showed a potential therapeutic target for AMD.
Area of Science:
- Ophthalmology
- Immunology
- Pulmonology
Background:
- Age-related macular degeneration (AMD) and asthma involve complement system activation.
- Previous studies have yielded conflicting results regarding the association between AMD and asthma.
Purpose of the Study:
- To systematically investigate the relationship between AMD and asthma.
- To explore the underlying mechanisms connecting asthma and AMD pathogenesis.
Main Methods:
- Epidemiological analysis and meta-analysis.
- Animal model studies using rats with asthma.
- Fluorescein angiography (FA), histological analysis, and Western blot.
- In vivo study of compstatin's effect on choroidal neovascularization (CNV).
Main Results:
- Asthma showed a significant association with the choroidal neovascularization (CNV) subtype of AMD (OR=1.721, P=0.023).
- Animal models exhibited increased CNV leakage and angiogenesis in asthmatic rats.
- Elevated levels of complement C3 and vascular endothelial growth factor (VEGF) were observed.
- Compstatin treatment reduced CNV leakage and decreased C3 and VEGF levels.
Conclusions:
- Asthma may serve as a risk factor for AMD development.
- Findings suggest a potential role for the complement system and VEGF in asthma-related AMD.
- This research may improve understanding and clinical screening of asthma patients for AMD risk.
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