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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome

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Peromyscus as a Mammalian epigenetic model.

Kimberly R Shorter¹, Janet P Crossland, Denessia Webb

¹Peromyscus Genetic Stock Center and Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.

Genetics Research International

|May 9, 2012

Summary

Deer mice (Peromyscus) are valuable for studying natural genetic and epigenetic variations. Their unique traits and well-documented life histories make them ideal models for behavioral and environmental research.

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Area of Science:

Genetics and Epigenetics
Mammalian Model Organisms

Background:

Deer mice (Peromyscus) offer unique advantages for studying natural genetic and epigenetic variation.
Their diverse habitats, well-studied life histories, and available genomic resources (sequencing, genetic map, ESTs) support advanced research.
Existing research highlights interspecies epigenetic differences and substance effects on behavior.

Purpose of the Study:

To review existing epigenetic studies involving Peromyscus models.
To explore the potential of Peromyscus for linking natural genetic variants with environmental factors and epigenetic outcomes.
To present new data on diet-induced epigenetic effects on coat color.

Main Methods:

Review of current epigenetic research in Peromyscus.
Analysis of Peromyscus models for agouti overexpression to study diet effects on coat color.
Integration of genetic and environmental data within Peromyscus systems.

Main Results:

Peromyscus models demonstrate potential for studying epigenetic control across species and substance-induced behavioral changes.
New data show diet impacts coat color epigenetics in agouti-overexpressing Peromyscus.
The model effectively links genetic variation, environmental influences, and epigenetic modifications.

Conclusions:

Peromyscus models are highly promising for investigating the interplay between natural genetic variation, environmental factors, and epigenetic modifications.
Further research with Peromyscus can elucidate complex genotype-environment-epigenetic interactions.
The model system is well-suited for discovering how environmental exposures shape epigenetic landscapes.