Related Experiment Video
Updated: May 22, 2026

09:45
Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
Congenital syphilis like many years ago
Giulia Brighi1, Giorgia Farneti, Antonella Marangoni
1Neonatal Intensive Care Unit, S. Orsola-Malpighi Polyclinc, University of Bologna, 40138 Bologna, Italy.
Case Reports in Infectious Diseases
|May 9, 2012
Summary
Congenital syphilis can affect premature infants born to untreated mothers. Early antenatal screening and treatment in pregnant women are crucial to prevent neonatal syphilis transmission.
Area of Science:
- Neonatal infections
- Maternal-fetal medicine
- Infectious disease epidemiology
Background:
- Rising syphilis prevalence in pregnant women in Italy since the early 21st century.
- Immigration as a contributing factor to increased syphilis rates.
- Congenital syphilis presents significant risks to newborns.
Observation:
- Case study of a premature infant exhibiting classic symptoms of congenital syphilis.
- The infant's mother was untreated and of foreign origin.
- Highlights the potential for transmission from mother to child.
Findings:
- Untreated maternal syphilis is a direct cause of congenital syphilis.
- Neonatal presentation includes characteristic signs of the infection.
- Underscores the importance of maternal health in preventing infant disease.
Implications:
- Emphasizes the critical need for robust antenatal syphilis screening programs.
- Adequate therapy for pregnant women is essential to prevent congenital syphilis.
- Public health strategies must address rising syphilis rates in pregnant populations, particularly in diverse demographic groups.
Related Concept Videos
Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
Diphtheria
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Infectious Diseases and Their Occurrence
Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
