Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ivermectin and coagulation: an in vitro study.

J Hay1, M A Arnott

  • 1School of Pharmacy, Leicester Polytechnic.

Annals of Tropical Medicine and Parasitology
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation and responsiveness of the English version of the Chemotherapy-Induced Alopecia Distress Scale (CADS) in breast cancer patients.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2024
Same author

Validation and Responsiveness of the English version of the Chemotherapy-Induced Alopecia Distress Scale (CADS) in Breast Cancer Patients.

medRxiv : the preprint server for health sciences·2023
Same author

The Glasgow Microenvironment Score and risk and site of recurrence in TNM I-III colorectal cancer.

British journal of cancer·2022
Same author

Membrane filtration method for bacteriological testing of water: enhanced colony visualization and stability on purification of phenol red indicator.

Letters in applied microbiology·2021
Same author

SARS-CoV-2 Positivity in Asymptomatic-Screened Dental Patients.

Journal of dental research·2021
Same author

Non-Māori-speaking New Zealanders have a Māori proto-lexicon.

Scientific reports·2020
Same journal

Some observations upon the maintenance of Australorbis glabratus in the laboratory.

Annals of tropical medicine and parasitology·2014
Same journal

A new species of Phlebotomus (Diptera, Psychodidae) from Uganda.

Annals of tropical medicine and parasitology·2014
Same journal

The length of exposure to infestation and the danger of contracting onchocerciasis.

Annals of tropical medicine and parasitology·2014
Same journal

Observations on Chrysops silacea and C. dimidiata at Benin, Southern Nigeria. II.

Annals of tropical medicine and parasitology·2014
Same journal

Embryonated eggs of Ascaris lumbricoides in the wall of a human hernial sac.

Annals of tropical medicine and parasitology·2014
Same journal

Studies in the chemotherapy of cholera. VI. Protection by pteridines of mice infected with Vibrio cholerae.

Annals of tropical medicine and parasitology·2014
See all related articles

Ivermectin, an antiparasitic drug, did not affect blood clotting times in healthy human plasma during in vitro testing. These findings suggest ivermectin does not interfere with key coagulation parameters at therapeutic concentrations.

Area of Science:

  • Pharmacology
  • Hematology
  • Clinical Chemistry

Background:

  • Ivermectin is a widely used antiparasitic medication.
  • Understanding potential drug interactions with hemostasis is crucial for patient safety.

Purpose of the Study:

  • To investigate the in vitro effects of ivermectin on human plasma coagulation.
  • To determine if therapeutic concentrations of ivermectin alter prothrombin time, partial thromboplastin time with kaolin, or thrombin clotting time.

Main Methods:

  • Plasma from healthy human volunteers was used for coagulation testing.
  • Therapeutic concentrations of ivermectin (20-90 ng/mL) were added in vitro.
  • Standard coagulation assays including prothrombin time, partial thromboplastin time with kaolin, and thrombin clotting time were performed.

Related Experiment Videos

  • Incubation time with the drug was 12 hours.

    • Main Results:

    • Ivermectin addition did not significantly alter prothrombin time.
    • Partial thromboplastin time with kaolin remained unchanged after ivermectin exposure.
    • Thrombin clotting time showed no significant difference compared to untreated controls.
    • Coagulation tests were consistent after 12 hours of incubation with ivermectin.

    Conclusions:

    • Ivermectin at therapeutic concentrations does not appear to affect key human plasma coagulation parameters in vitro.
    • These findings suggest a low risk of ivermectin-induced interference with blood clotting mechanisms.