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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: May 22, 2026

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
07:01

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Published on: September 20, 2020

[Alpha power voluntary increasing training for cognition enhancement study].

M V Alekseeva, N V Balioz, K B Muravleva

    Fiziologiia Cheloveka
    |May 10, 2012
    PubMed
    Summary

    This study examined whether training people to voluntarily increase their brain's alpha waves while reducing muscle tension could improve cognitive skills. Researchers compared real biofeedback training against a fake, or sham, version in healthy young men. The results suggest that real training improves specific mental tasks and brain activity patterns, particularly in those starting with lower baseline alpha levels. These findings indicate that such training might be useful for enhancing mental performance and developing new brain-computer interface technologies.

    Keywords:
    neurofeedback trainingbrain-computer interfaceneural oscillationsmental performance

    Frequently Asked Questions

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    Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
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    High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity
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    High-definition Transcranial Direct Current Stimulation over Right Dorsolateral Prefrontal Cortex to Enhance Metacognitive Sensitivity

    Published on: September 26, 2025

    Area of Science:

    • Neuroscience and alpha power biofeedback training within cognitive psychology
    • Clinical neurophysiology and human performance research

    Background:

    Prior research has shown that brain oscillations relate to mental processing efficiency. No prior work had resolved whether voluntary control of these rhythms could directly boost cognitive output. Many studies focus on passive observation rather than active self-regulation of neural signals. That uncertainty drove the need to investigate specific training protocols involving both brain and muscle feedback. Current literature often lacks clarity on how baseline individual differences influence the success of such interventions. This gap motivated a rigorous comparison between active training and placebo conditions. Researchers previously struggled to isolate the specific impact of alpha modulation from general relaxation effects. This study addresses these limitations by examining long-term follow-up data after repeated training sessions.

    Purpose Of The Study:

    The aim of this study was to evaluate the impact of simultaneous brain and muscle biofeedback training on neural activity and mental functions. Researchers sought to determine if voluntary regulation of specific brain waves could improve cognitive performance. The study addressed the uncertainty regarding how such training influences individual differences in baseline neural states. This investigation specifically targeted the role of alpha-activity in enhancing conceptual span and task flexibility. The team intended to clarify whether real feedback provides superior outcomes compared to placebo conditions. By comparing real and sham groups, the authors aimed to isolate the specific effects of the training protocol. This effort was motivated by the potential for these techniques to serve clinical and technological needs. The study provides a structured analysis of how self-regulation training affects both immediate and long-term cognitive outcomes.

    Main Methods:

    Review approach involved a controlled trial with twenty-seven healthy male volunteers aged eighteen to thirty-four. Investigators divided participants into two distinct groups to test the efficacy of the intervention. One cohort received real-time feedback, while the other group underwent a sham procedure for comparison. The team conducted ten separate sessions to facilitate the voluntary regulation of neural signals. Researchers monitored both brain electrical activity and muscle tension throughout each session to ensure precise feedback delivery. They evaluated performance using conceptual span tasks alongside assessments of fluency and flexibility in alternative usage. The study design included a follow-up assessment one month after the training concluded to track long-term changes. This structured approach allowed for the clear discrimination of the feedback role in modulating neural and mental states.

    Main Results:

    Key findings from the literature indicate that real training significantly enhanced cognitive fluency and accuracy compared to the sham condition. Participants with low baseline alpha frequency showed increased resting frequency, width, and power in their individual upper alpha range. Conversely, mock feedback only influenced resting alpha power in those with high baseline levels and failed to improve mental performance. The active training successfully prevented the typical alpha power decrease during arithmetic tasks. This protective effect remained evident during the one-month follow-up period. In contrast, the sham group demonstrated no such sustained neural stability or cognitive improvement. These results suggest that the specific feedback mechanism is essential for the observed neural and behavioral changes. The data confirm that baseline characteristics strongly influence the responsiveness of individuals to this type of neurofeedback.

    Conclusions:

    The authors suggest that combined brain and muscle feedback serves as a viable tool for improving mental performance. Synthesis and implications indicate that these training protocols offer potential benefits for clinical practice. Researchers propose that the observed improvements in cognitive fluency and accuracy stem from successful self-regulation of neural rhythms. The study highlights that baseline individual differences dictate the efficacy of these interventions. These findings imply that such methods could support the development of advanced brain-computer interface technology. The authors note that the training effects persist for at least one month after the sessions conclude. This evidence supports the use of these techniques for both enhancement and prognostic purposes. Future applications might leverage these specific neurofeedback parameters to optimize human cognitive capacity.

    The researchers propose that the training improves cognitive fluency and accuracy by enabling voluntary control over neural oscillations. Unlike the sham group, participants receiving real feedback showed significant gains in mental task performance, particularly those starting with lower baseline alpha frequencies.

    The study utilized a dual-feedback approach, simultaneously monitoring electroencephalography (EEG) for brain activity and electromyography (EMG) for muscle tension. This combined method aimed to increase alpha power while reducing physical strain during the ten training sessions.

    The authors indicate that the training is necessary to eliminate the typical alpha power decline observed during demanding arithmetic tasks. This protective effect against mental fatigue was sustained for one month, whereas the sham group failed to demonstrate any such long-term neural stability.

    The researchers used individual upper alpha range data to calibrate the feedback. This measurement allowed them to tailor the training to each subject's unique neural profile, ensuring that the biofeedback was relevant to their specific baseline resting frequency.

    The study measured resting frequency, width, and power within the individual upper alpha range. These metrics revealed that real training increased these indices specifically in participants who began with low baseline alpha levels, contrasting with the sham group's lack of improvement.

    The authors propose that their findings support the use of this training for prognostic aims in clinical settings. They suggest that the ability to modulate brain rhythms could serve as a valuable indicator for patient assessment and future brain-computer interface development.