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Updated: May 22, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Synthesis, characterization and evaluation of mannich bases as potent antifungal and hydrogen peroxide scavenging
Manav Malhotra1, Rajiv Sharma, Mohit Sanduja
1Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozepur Road, Moga-142 001, India.
Abstract:
In the present study, (E)-2-{ [-2-(2,4-Dinitrophenyl)hydrazono]methyl} phenol (3) was synthesized and used as key intermediate for the synthesis of new Mannich bases. All the synthesized compounds were evaluated for their antifungal activity against three fungal strains Candida albicans, Candida tropicalis and Aspergillus niger and antioxidant activity. The structure of these compounds was confirmed by IR, 1H NMR and 13C NMR studies. Most of the compounds exhibited moderate to significant activities.
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