Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

Ophthalmic Drug Delivery Systems

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Age-dependent association of the METTL23 c.84+60delAT variant with normal-tension glaucoma.

Journal of human genetics·2026

Same author

Clinical determinants of retinal age gap estimated from fundus photographs in glaucoma patients.

Scientific reports·2026

Same author

Genetic factors associated with response to as-needed brolucizumab treatment for exudative age-related macular degeneration.

Japanese journal of ophthalmology·2026

Same author

Treatment Persistence with Combination Eye Drops for Glaucoma: A Longitudinal Analysis Using Japanese Medical Claims Data.

Ophthalmology and therapy·2026

Same author

Disparity of ophthalmic surgeries in Japan.

PloS one·2026

Same author

The potential role of the choroidal thickness-to-axial length ratio in primary angle-closure disease.

Japanese journal of ophthalmology·2026

Search research articles

Related Experiment Video

Updated: May 22, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

[Toward a high quality glaucoma care].

Kenji Kashiwagi¹

¹Department of Community and Family Medicine, University of Yamanashi, Chuo-shi, Yamanashi-ken, Japan. kenjik@yamanashi.ac.jp

Nippon Ganka Gakkai Zasshi

|May 10, 2012

Summary

This summary is machine-generated.

Researchers developed new tools and systems to improve glaucoma care, including advanced diagnostics, novel treatments, and telemedicine platforms. These innovations aim to enhance patient outcomes and accessibility in glaucoma management.

More Related Videos

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Related Experiment Videos

Last Updated: May 22, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Area of Science:

Ophthalmology
Neuroscience
Biomaterials Science

Context:

Glaucoma care faces challenges including early detection, patient adherence, and specialist shortages.
Retinal ganglion cell (RGC) survival and neurite growth are critical in neurodegenerative optic neuropathies.
Advancements in diagnostic tools and therapeutic strategies are needed for effective glaucoma management.

Purpose:

To develop and evaluate novel diagnostic tools for angle closure and open-angle glaucoma.
To investigate the role of glial cells and SRC kinase in RGC survival and neurite growth.
To create and assess innovative solutions for improving patient adherence and healthcare accessibility in glaucoma.

Summary:

A scanning peripheral anterior chamber depth analyzer was developed for screening and monitoring glaucoma.
Studies explored glial cell and SRC kinase involvement in RGC survival, using gene-targeted mice and in vitro models.
A chitosan-sodium alginate implant was developed for intraocular pressure (IOP) reduction, and ICT-based support and telemedicine systems were established to enhance glaucoma care delivery.

Impact:

The developed technologies and systems offer potential for earlier glaucoma detection, improved treatment efficacy, and enhanced patient engagement.
The research provides insights into neuroprotective strategies for RGCs, potentially leading to new therapeutic avenues.
Integrated telemedicine and patient support systems promise to revolutionize glaucoma care, addressing accessibility and specialist limitations.