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Updated: May 22, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

[Interferon]

Akihiro Tamori1, Norifumi Kawada

  • 1Department of Hepatology, Osaka City University Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 10, 2012
PubMed

More than 50 years have passed since interferon (IFN) was discovered. Until now, the signaling pathway and function of IFN were basically elucidated. IFN has been clinically used for patients with hepatitis B virus (HBV) or hepatitis C virus (HCV). In Japan, pegylated IFN (PEG-IFN) is just approved for patients with HBV related chronic hepatitis. Also, the adding of direct-acting antiviral agents to the combination therapy with PEG-IFN plus ribavirin will improve anti-HCV effect. Another important effect of IFN is a suppression of hepatocarcinogenesis in patients with viral related chronic liver diseases. Maintenance therapy with low dose of PEG-IFN or IFN can improve the prognosis of patients with advanced hepatic fibrosis.

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