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Urinary tract infection caused by carbapenem-resistant K. pneumoniae and P. aeruginosa

Ioana D Olaru1, Mona Popoiu, J Breuil

  • 1Prof. Dr. Matei Balş National Institute of Infectious Diseases, Bucharest, Romania. ioanad_olaru@yahoo.co.uk

Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne
|May 10, 2012
PubMed

Insights

Antimicrobial resistance in Gram-negative bacilli (GNB) is rising, limiting treatment options. A case study highlights colistin

Area of Science:

  • Medical microbiology
  • Infectious diseases
  • Antimicrobial resistance

Background:

  • Rising antimicrobial resistance in Gram-negative bacilli (GNB) poses a significant global health threat.
  • Carbapenems, crucial for treating multidrug-resistant GNB infections, are becoming less effective.
  • Limited treatment alternatives necessitate understanding resistance mechanisms and effective management strategies.

Observation:

  • A patient presented with recurrent, complicated urinary tract infections.
  • Infections involved carbapenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa, alongside carbapenem-susceptible but multidrug-resistant Enterobacter cloacae.
  • Klebsiella pneumoniae exhibited carbapenem resistance due to VIM1 metallo-beta-lactamase production.

Findings:

  • A 2-week course of colistin effectively treated the carbapenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa infections.
  • The patient's infection resolved, leading to successful discharge.
  • Implementation of infection control measures was crucial in managing the multidrug-resistant organisms.

Implications:

  • Highlights the increasing challenge of carbapenem resistance in Gram-negative bacilli.
  • Emphasizes colistin as a viable treatment option for carbapenem-resistant Gram-negative infections.
  • Stresses the critical role of infection control in preventing the spread of multidrug-resistant organisms and preserving limited therapeutic options.

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