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Updated: May 22, 2026

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
Published on: December 30, 2025
[Fetal Parvowirus B19 infection with hydrops fetalis, a case report]
Karina Engel1, Piotr Grabarczyk, Zbigniew Celewicz
1Klinika Medycyny Matczyno-Płodowej i Ginekologii Pomorskiego UM w Szczecinie, Polska. karina@engel.net.pl
Abstract:
Parvovirus B19 (B19V) infection during pregnancy is a cause of nonimmune hydrops. We report a case of hydrops fetalis with severe fetal anemia in the course of B19V infection in the third trimester of pregnancy. Maternal and fetal parvovirus B19 infection was confirmed using quantitative real time PCR detection of viral DNA. The affected fetus was treated with three intrauterine transfusions. The baby was delivered by caesarean section at 36 weeks. Up until 6 months of age no abnormalities in the development of the child were observed.
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