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Published on: February 14, 2018
Miconazole, a pharmacological barrier to skin fungal infections
Gérald E Piérard1, Trinh Hermanns-Lê, Philippe Delvenne
1University Hospital of Liège, Department of Dermatopathology, CHU Sart Tilman, B-4000 Liège, Belgium. gerald.pierard@ulg.ac.be
Introduction:
Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14α-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes. In addition, intracellular accumulation of toxic methylated sterols occurs and the synthesis of triglycerides and phospholipids is altered. Disturbances in oxidative and peroxidative enzyme activities lead to an intracellular toxic concentration of hydrogen peroxide. As a result, intracellular organelle destruction then leads to cell necrosis. Farnesol synthesis stimulated in Candida spp. prevents the yeast-to-mycelium formation. MCZ is further active against Gram-positive bacteria.
Areas Covered:
This review aims at revisiting the MCZ antifungal activity in dermatomycoses.
Expert Opinion:
MCZ's wide spectrum of activity appears noteworthy. The full pharmacological profile of MCZ indicates its fungistatic profile through its effect on ergosterol biosynthesis. In addition, it exhibits a fungicidal effect against a number of fungal species, due to hydrogen peroxide accumulation. MCZ is characterized by high safety, efficacy and versatility, and a unique, multifaceted nature of activity in the treatment of dermatomycoses.
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