Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The roles of neuroticism, genetic susceptibility, and amygdala structure in chronic musculoskeletal pain onset and recovery.

Communications medicine·2026
Same author

Effects of transcutaneous auricular nerve stimulation on thalamic relay: A randomized brain imaging study in chronic low back pain patients.

Brain research·2026
Same author

Blue cone monochromacy with parafoveal hyperautofluorescent ring caused by a novel OPN1LW p.Ile109Asn variant.

Documenta ophthalmologica. Advances in ophthalmology·2026
Same author

Telehealth-delivered multimodal mind-body intervention for mild cognitive impairment: a randomized feasibility trial toward scalable dementia prevention.

NPJ dementia·2026
Same author

Effect of Acupuncture for Chronic Nonspecific Low Back Pain: Study Protocol for a Randomized Double-Blind, Placebo-Controlled Trial.

JMIR research protocols·2026
Same author

Discovery of lactylation-associated candidate hub genes and potential curcumin targets in intervertebral disc degeneration.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same journal

Genetic analysis of imaging-derived phenotypes.

Nature reviews. Genetics·2026
Same journal

Genetic origins and constraints of evolutionary innovation.

Nature reviews. Genetics·2026
Same journal

Single-cell four-omics with CHARM.

Nature reviews. Genetics·2026
Same journal

Molecular integration of seasonal temperature signals in flowering time control.

Nature reviews. Genetics·2026
Same journal

RBPscan measures protein-RNA interactions in living cells.

Nature reviews. Genetics·2026
Same journal

Revisiting retinal and macular degeneration in the genomics era.

Nature reviews. Genetics·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

Translational control in cellular and developmental processes.

Jian Kong1, Paul Lasko

  • 1Department of Biology, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec H3G 0T5, Canada.

Nature Reviews. Genetics
|May 10, 2012
PubMed
Summary
This summary is machine-generated.

Translational control of messenger RNAs (mRNAs) is crucial for genetic regulation. New discoveries reveal novel mechanisms and links to human diseases, impacting cellular and developmental processes.

More Related Videos

Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells
14:29

Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells

Published on: December 25, 2021

Toeprinting Analysis of Translation Initiation Complex Formation on Mammalian mRNAs
10:37

Toeprinting Analysis of Translation Initiation Complex Formation on Mammalian mRNAs

Published on: May 10, 2018

Related Experiment Videos

Last Updated: May 22, 2026

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale
10:56

Polysome Fractionation and Analysis of Mammalian Translatomes on a Genome-wide Scale

Published on: May 17, 2014

Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells
14:29

Rapid In Vivo Fixation and Isolation of Translational Complexes from Eukaryotic Cells

Published on: December 25, 2021

Toeprinting Analysis of Translation Initiation Complex Formation on Mammalian mRNAs
10:37

Toeprinting Analysis of Translation Initiation Complex Formation on Mammalian mRNAs

Published on: May 10, 2018

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Translational control of specific messenger RNAs (mRNAs) plays a vital role in genetic regulation.
  • Protein synthesis from mRNA is regulated by RNA-binding proteins during initiation and elongation.
  • Translational control is often linked to mRNA localization mechanisms.

Purpose of the Study:

  • To explore novel modes of translational regulation.
  • To gain insights into how specific regulators interact with the general translational machinery.
  • To identify new connections between translational control and human diseases.

Main Methods:

  • Analysis of recent discoveries from invertebrate and vertebrate systems.
  • Investigation of RNA-binding protein interactions.
  • Comparative studies across different biological systems.

Main Results:

  • Uncovered novel mechanisms of translational regulation.
  • Provided new insights into the targeting of the translational machinery.
  • Identified several new links between translational control and human diseases.

Conclusions:

  • Translational control is a fundamental aspect of genetic regulation.
  • Emerging research highlights diverse regulatory strategies and disease associations.
  • Further investigation into translational control mechanisms is warranted.