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Updated: May 22, 2026

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging
Published on: April 6, 2014
Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries
Aruni S Arachchige Don1, Chi Kwan Tsang, Tatiana M Kazdoba
1Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School (RWJMS), Piscataway, NJ 08854, USA.
Abstract:
The adult central nervous system (CNS) has a remarkable ability to repair itself. However, severe brain and spinal cord injuries (SCIs) cause lasting disability and there are only a few therapies that can prevent or restore function in such cases. In this review, we provide an overview of traumatic CNS injuries and discuss several emerging pharmacological options that have shown promise in preclinical and early clinical studies. We highlight therapies that modulate mammalian target of rapamycin (mTOR) signaling, a pathway that is well known for its roles in cell growth, metabolism and cancer. Interestingly, this pathway is also gaining newfound attention for its role in CNS repair and regeneration.
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