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Cerebral blood volume changes during brain activation.

Steffen Norbert Krieger1, Markus Nikolar Streicher, Robert Trampel

  • 1Department of Neurophysics, Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. Krieger@cbs.mpg.de

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|May 10, 2012
PubMed
Summary
This summary is machine-generated.

Cerebral blood volume (CBV) changes during brain activity are explained by water exchange between capillaries and tissue. This resolves the paradox of pressure changes within the skull, supporting CBV as a neural activity marker.

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Area of Science:

  • Neuroscience
  • Biophysics
  • Medical Imaging

Background:

  • Cerebral blood volume (CBV) changes with brain activation, measurable via PET, fMRI, and optical microscopy.
  • Assuming impermeable vessels and incompressible skull contents leads to a paradox: CBV changes could cause dangerous intracranial pressure increases.
  • CBV is a promising marker for neural activity, necessitating a resolution to this paradox.

Purpose of the Study:

  • To investigate the role of water exchange between capillaries and tissue in facilitating CBV changes.
  • To resolve the apparent paradox between CBV changes and intracranial pressure.

Main Methods:

  • Developed a novel hemodynamic boundary-value model with numerical solutions.
  • Constructed a macroscopic experimental model of a single capillary.
  • Modeled capillary membranes as elastic and permeable in both theory and experiment.

Main Results:

  • The experimental setup showed a relative pipe volume change of 21±5% for a realistic input pressure change.
  • The mathematical model predicted a similar quantity of approximately 17±1%.
  • Observed volume, axial flow, and pressure changes were within expected physiological ranges.

Conclusions:

  • Water exchange across permeable, elastic capillary membranes facilitates CBV changes.
  • This mechanism resolves the paradox of intracranial pressure changes during neural activation.
  • Supports the utility of CBV as a localized marker of neural activity.