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Dual promoters and tissue-specific expression of rat transthyretin gene
1Department of Biochemistry, School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
Biochemical and Biophysical Research Communications
|November 30, 1990
Abstract:
The rat chromosomal gene for transthyretin was cloned and its dual promoter region was analyzed by primer extension. Semi-quantitative studies by primer extension analysis to determine the transcriptional start sites and their usage in the three tissues have suggested that the rat transthyetin gene has dual promoters: a major proximal promoter which is used in the liver and in the brain but not at all in the kidney, and a minor distal promoter which is totally used in the kidney and significantly in the brain.