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Corneal collagen crosslinking in refractive surgery.

Anjum S Cheema1, Arash Mozayan, Prabjot Channa

  • 1Department of Ophthalmology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467, USA. pchanna@montefiore.org

Current Opinion in Ophthalmology
|May 10, 2012
PubMed
Summary

Corneal collagen crosslinking (CXL) effectively treats progressive keratoconus and post-LASIK ectasia by stiffening the cornea. This promising treatment can improve vision and prevent the need for more invasive surgeries.

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Biomaterials Science

Background:

  • Keratoconus and post-LASIK keratectasia are progressive conditions leading to corneal ectasia.
  • Current treatments often involve invasive procedures with variable outcomes.

Purpose of the Study:

  • To review the development and applications of corneal collagen crosslinking (CXL).
  • To evaluate CXL in treating progressive keratoconus and post-LASIK keratectasia.
  • To explore CXL combined with keratorefractive procedures.

Main Methods:

  • Corneal collagen crosslinking (CXL) involves using riboflavin and ultraviolet A light to stiffen corneal tissue.
  • Studies reviewed include those combining CXL with intrastromal corneal ring segments and photorefractive keratectomy.

Main Results:

  • CXL effectively slows, halts, or reverses corneal ectasia by increasing corneal stiffness.
  • Combined CXL and keratorefractive procedures show promise in improving visual acuity and stabilizing ectasia.
  • This approach may delay or prevent the need for corneal transplantation.

Conclusions:

  • CXL is a valuable treatment for progressive keratoconus and post-LASIK keratectasia.
  • Further research is required to ascertain the long-term efficacy and safety of CXL.