Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Nose and Nasal Cavity01:24

Nose and Nasal Cavity

The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hearing loss and executive functions - results from a population-based cohort study.

PloS one·2026
Same author

Immunoadsorption Versus Sham Treatment for Post-COVID Syndrome: A Randomised Sham-Controlled Crossover Trial.

The Lancet regional health. Europe·2026
Same author

Accuracy and precision of continuous, non-invasive blood pressure devices: a systematic review and meta-analyses.

Anaesthesia·2026
Same author

Amblyopia and strabismus: Psychosocial characteristics - results from the Gutenberg Health Study (GHS).

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism.

The New England journal of medicine·2026
Same author

Increased albuminuria is highly prevalent in the general population: prevalence of CKD in the Gutenberg Health Study.

Clinical kidney journal·2026

Related Experiment Video

Updated: May 22, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Low SPINK5 expression in chronic rhinosinusitis.

Kai Fruth1, Gyula Goebel, Dimitrios Koutsimpelas

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany. kai.fruth@unimedizin-mainz.de

The Laryngoscope
|May 10, 2012
PubMed
Summary

SPINK5 gene variations are linked to aspirin intolerance in chronic rhinosinusitis (CRS) patients. Lowered SPINK5 expression may contribute to CRS, particularly in those with allergies and aspirin intolerance.

More Related Videos

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas
10:25

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas

Published on: June 12, 2019

Related Experiment Videos

Last Updated: May 22, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas
10:25

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas

Published on: June 12, 2019

Area of Science:

  • Immunology
  • Genetics
  • Otolaryngology

Background:

  • Chronic rhinosinusitis (CRS) is a complex condition influenced by genetic and environmental factors.
  • SPINK5, a serine protease inhibitor, is crucial for maintaining epithelial barrier function.
  • The specific roles of SPINK5 gene polymorphisms and expression in CRS, especially concerning aspirin intolerance, remain largely uncharacterized.

Purpose of the Study:

  • To investigate the association between SPINK5 single-nucleotide polymorphisms (SNPs) and SPINK5 expression levels with CRS phenotypes (CRSsNP and CRSwNP).
  • To determine the correlation of SPINK5 status with aspirin intolerance, asthma, and allergies in CRS patients.

Main Methods:

  • Analysis of SPINK5 genotypes (G1258A, G2475T, A2915G, A1103G) and mRNA expression in 104 nasal tissue samples (15 CRSsNP, 59 CRSwNP, 30 controls).
  • Correlation of SPINK5 SNPs and expression levels with clinical data including CRS type, aspirin intolerance, asthma, and allergies using polymerase chain reaction.

Main Results:

  • No significant correlation was found between SPINK5 SNPs and CRSsNP, CRSwNP, asthma, or allergies.
  • Heterozygous G1258A and A1103G SPINK5 SNPs were more prevalent in aspirin-intolerant patients, while homozygous genotypes were less frequent.
  • Lowered SPINK5 expression was observed in patients with CRSwNP, aspirin intolerance, and allergies, independent of analyzed SPINK5 SNPs.

Conclusions:

  • SPINK5 polymorphisms G1258A and A1103G are specifically associated with the aspirin intolerance syndrome.
  • Reduced SPINK5 expression may be a contributing factor to the development of CRS.
  • Diminished SPINK5 expression appears characteristic of CRS patients who also suffer from aspirin intolerance and allergies.