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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Updated: May 22, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
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Published on: October 13, 2023

Intrauterine environment and multiple sclerosis: a population- based case-control study.

Beth A Mueller1, J Lee Nelson, Polly A Newcomb

  • 1Public Health Sciences Division, Fred Hutchinson Cancer Research Center, USA. bmueller@fhcrc.org

Multiple Sclerosis (Houndmills, Basingstoke, England)
|May 10, 2012
PubMed
Summary
This summary is machine-generated.

Maternal prenatal smoking increased the risk of multiple sclerosis (MS) hospitalization, while having more siblings or higher maternal birth numbers decreased it. These findings suggest early life exposures may influence MS development.

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Area of Science:

  • Neurology
  • Epidemiology
  • Environmental Health

Background:

  • Autoimmune disorders, including multiple sclerosis (MS), have been linked to early life exposures.
  • Understanding these associations is crucial for identifying potential preventative strategies.

Purpose of the Study:

  • To investigate the relationship between maternal, prenatal, and infant factors and MS-related hospitalizations.
  • Utilized population-based linked hospital discharge and birth records in Washington State.

Main Methods:

  • A population-based case-control study design was employed.
  • 272 MS hospitalization cases and 2720 birth record controls were analyzed.
  • Birth record data were used to compare exposure information and estimate odds ratios (ORs) and 95% confidence intervals (95%CIs).

Main Results:

  • Maternal prenatal smoking showed a positive association with MS hospitalization (OR 3.09).
  • Higher maternal parity (3+ births) and more older siblings (3+) were negatively associated with MS hospitalization (ORs 0.54 and 0.49, respectively).
  • Most other examined factors were not significantly associated with MS hospitalization.

Conclusions:

  • Prenatal exposure to smoke constituents may contribute to MS risk.
  • The protective associations with parity and siblings suggest complex multifactorial influences on MS development.
  • Further research is needed to explore childhood and adult exposures and their impact on MS.