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Published on: November 6, 2018
Sick cell syndrome in a burned patient
J Benito Ruiz1, P Baena Montilla, A Navarro Monzonis
1Burn Centre, Hospital La Fe, Valencia, Spain.
Summary
Sick cell syndrome, a cellular sodium-potassium pump disorder, can be triggered by sepsis or malnutrition. Prompt treatment of the underlying cause resolves symptoms like hyponatremia and confusion.
Area of Science:
- Biochemistry
- Cellular Biology
- Internal Medicine
Background:
- Sick cell syndrome is a cellular disorder affecting the sodium-potassium (Na+/K+) pump.
- Potential causes include hypoxia, sepsis, hypovolemia, and malnutrition.
Observation:
- A patient in a Burn Centre experienced recurrent sick cell syndrome.
- The first episode was linked to hyponutrition; the second to septicemia.
- Key clinical features included hyponatremia, reduced natriuria, and neurological symptoms like confusion and hallucinations.
Findings:
- Hyponatremia persisted despite increased sodium intake.
- Hematological parameters remained stable.
- Hyperkalemia showed an upward trend.
Implications:
- This case highlights the diverse triggers and clinical presentation of sick cell syndrome.
- Effective management relies on identifying and treating the root cause.
- Understanding the Na+/K+ pump's role is crucial for managing complex metabolic disturbances.
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