Related Experiment Video
Updated: May 22, 2026
07:01
A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
Published on: February 7, 2025
A pediatric Conn syndrome case
Asan Onder1, Havva Nur Peltek Kendirci, Veysel Nijat Bas
1Pediatric Endocrinology Clinic, Dr. Sami Ulus Gynecology & Obstetrics and Pediatrics Training and Research Hospital, Ankara, Turkey. asanonder@yahoo.com
Summary
Conn syndrome, a rare childhood condition causing hypertension, was successfully treated in a 15-year-old girl. Surgical removal of an adrenal adenoma normalized aldosterone levels, resolving her hypertension.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Medicine
- Nephrology
Background:
- Conn syndrome (primary aldosteronism) is rare in children, presenting with hypertension, hypokalemia, and alkalosis due to excess aldosterone.
- Potential severe complications include endothelial dysfunction and impaired cardiovascular function.
Observation:
- A 15-year-old girl presented with severe hypertension and headache, diagnosed with primary aldosteronism.
- Biochemical analysis revealed hypokalemia, alkalosis, low plasma renin activity, and elevated aldosterone levels.
- Abdominal MRI identified a left adrenal adenoma, leading to left adrenalectomy.
Findings:
- Post-surgery, aldosterone levels normalized, but hypertension persisted initially.
- Antihypertensive treatment was discontinued after 10 months as blood pressure normalized.
- The patient remained normotensive during a 15-month follow-up without medication.
Implications:
- This case highlights the importance of considering and diagnosing primary aldosteronism in pediatric hypertension.
- Surgical intervention for adrenal adenomas can effectively manage Conn syndrome in adolescents.
- Long-term normotension is achievable post-adrenalectomy, allowing for treatment cessation.
Related Concept Videos
01:11Pyloric Obstruction
Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
01:22Case Studies
There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
01:28Conduct Disorder
Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:26Esophageal Strictures-II: Clinical Features and Management
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
01:26Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...