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Updated: May 22, 2026

Hydrolysis of a Ni-Schiff-Base Complex Using Conditions Suitable for Retention of Acid-labile Protecting Groups
Published on: April 6, 2017
Acylhydrazide Schiff bases: DPPH radical and superoxide anion scavengers
Khalid Mohammed Khan1, Muhammad Taha, Farzana Naz
1H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk
Abstract:
Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC(50) values between 31.25-473.59 µM. Compounds 8, 2, and 10 have IC(50) values 31.25 ± 1.32, 34.40 ± 0.66, and 37.24 ± 0.4 µM, respectively. Standard npropylgallate showed an IC(50) value 30.12 ± 0.27 µM. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC(50) values in the range of 175.6-450.89 µM. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC(50) = 106.34 ± 1.6 µM).
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