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Selection at the ABO locus in the Japanese population
1Department of Zoology, University of Texas, Austin 78212.
Idengaku Zasshi
|June 1, 1990
Summary
Maternal-fetal ABO incompatibility did not affect prenatal death frequency in Japanese cities. However, A-fetus viability was higher, reducing prenatal deaths with increased A-fetus probability.
Area of Science:
- Human Genetics
- Reproductive Biology
- Population Genetics
Background:
- Previous studies suggested maternal-fetal ABO incompatibility impacts prenatal death rates.
- Hiraizumi et al. (1973b) found no overall effect in Ohdate and Akita, Japan, but noted heterogeneity in prenatal death frequencies across mating types.
Purpose of the Study:
- To further analyze the relationship between ABO blood group incompatibility and prenatal death frequency.
- To investigate the hypothesis that A-bearing fetuses have higher viability.
Main Methods:
- Analysis of prenatal death frequencies across 16 mating types.
- Examination of average prenatal deaths and pregnancies per couple in relation to the probability of producing A-bearing fetuses.
Main Results:
- The study confirmed that prenatal death frequency decreases as the probability of producing A-bearing fetuses increases.
- Prenatal losses are similar between matings producing and not producing A-bearing fetuses.
- A-bearing fetuses experience more frequent early-stage losses, often unrecognized.
Conclusions:
- While early loss stages differ, net prenatal losses are comparable for A-bearing and other fetuses.
- These differential loss stages do not significantly alter observed segregation frequencies in offspring.