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Updated: May 22, 2026
06:15
Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
[Bronchiolitis obliterans after Stevens-Johnson syndrome].
Eline A M Zijtregtop1, Mariëlle W Pijnenburg, Bart L Rottier
1Erasmus Medisch Centrum - Sophia Kinderziekenhuis, afd. Kindergeneeskunde, Rotterdam, the Netherlands.
Nederlands Tijdschrift Voor Geneeskunde
|May 11, 2012
Summary
Bronchiolitis obliterans, a severe lung disease, can develop after Stevens-Johnson syndrome. Lung transplantation may be the only effective treatment for this irreversible airway obstruction.
Area of Science:
- Pulmonology
- Critical Care Medicine
Background:
- Bronchiolitis obliterans is a severe, irreversible obstructive lung disease.
- It often follows lung transplantation, bone marrow transplantation, or respiratory infections.
- Diagnosis typically requires an open lung biopsy, with symptomatic treatment to prevent further damage.
Observation:
- An 8-year-old girl presented with pneumonia, followed by Stevens-Johnson syndrome and severe dyspnea.
- Chest CT scans indicated bronchiolitis obliterans, and methylprednisone therapy was ineffective.
- The patient underwent a successful lung transplantation due to respiratory insufficiency.
Findings:
- Bronchiolitis obliterans can be a complication of Stevens-Johnson syndrome.
- Progressive respiratory symptoms and characteristic CT findings suggest this condition.
- Lung transplantation is a viable therapeutic option for severe cases.
Implications:
- Clinicians should consider bronchiolitis obliterans in patients with progressive respiratory symptoms post-Stevens-Johnson syndrome.
- Early recognition and consideration of lung transplantation are crucial.
- This case highlights a rare but serious complication and its management.
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