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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Multiple Halogenation of Methyl Ketones: Haloform Reaction01:28

Multiple Halogenation of Methyl Ketones: Haloform Reaction

A method involving the transformation of methyl ketones to carboxylic acids using excess base and halogen is called the haloform reaction. It begins with the deprotonation of α hydrogen to form an enolate ion which reacts with the electrophilic halogen to give an α-halo ketone. The step continues until all the α protons are substituted to form a trihalomethyl ketone. The resulting molecule is unstable, and in the presence of a hydroxide base, it readily undergoes nucleophilic acyl substitution.
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...

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Related Experiment Video

Updated: May 22, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Dermatofibroma and halo dermatitis.

Clare Schofield1, David Weedon, Sandeep Kumar

  • 1Royal Hobart Hospital, Hobart, Tasmania, Australia. ccschofield@hotmail.com

The Australasian Journal of Dermatology
|May 11, 2012
PubMed
Summary

The Meyerson phenomenon, or halo dermatitis, is an inflammatory reaction around skin lesions. This rare case shows it can occur around dermatofibromas, not just moles, broadening its known clinical relevance.

Area of Science:

  • Dermatology
  • Dermatopathology

Background:

  • The Meyerson phenomenon, characterized by a halo of dermatitis, was first described around acquired naevi.
  • Histological features include spongiosis, parakeratosis, acanthosis, and a lymphocytic infiltrate.

Observation:

  • A rare case of Meyerson phenomenon occurred around a dermatofibroma in a 69-year-old woman.
  • This presentation is unusual as the phenomenon is typically associated with acquired naevi.

Findings:

  • The Meyerson phenomenon can manifest around various cutaneous lesions beyond acquired naevi.
  • Histopathological examination confirmed the characteristic inflammatory changes of halo dermatitis surrounding the dermatofibroma.

Implications:

  • This case expands the clinical spectrum of the Meyerson phenomenon.

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  • Dermatologists should consider halo dermatitis in the differential diagnosis for inflammatory reactions around diverse skin lesions, not exclusively in younger individuals or around naevi.