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Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Synthesis of polysubstituted 2-piperidinones via a Michael addition/nitro-Mannich/lactamization cascade
Hui Liu1, Zhengquan Zhou, Qian Sun
1School of Chemistry and Chemical Engineering, Yangzhou University , 180 Siwangting Street, Yangzhou 225002, P. R. China.
Abstract:
An efficient and practical method has been developed for the diversity-oriented synthesis of polysubstituted 2-piperidinones via four-component reaction between substituted nitrostyrenes, aromatic aldehydes, ammonium acetate, and dialkyl malonates for the generation of a wide range of structurally interesting and pharmacologically significant compounds. It is worth mentioning that in the course of this reaction, the formation of products was highly stereoselective. Two differently stereochemical classes of polysubstituted 2-piperidinones depended on the substitutent position of aromatic aldehyde.
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