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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport01:19

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview01:25

Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview

Drug administration can occur through various routes, each of which may result in a different process of elimination. This process is often mixed with nonlinear and linear processes. It's important to understand that a single drug can be metabolized into different metabolites through parallel processes.
For instance, consider the metabolism of sodium salicylate. This compound is metabolized into two distinct substances: a glucuronide and a glycine conjugate. The rate of conjugation depends on...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Related Experiment Video

Updated: May 22, 2026

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis
11:09

Characterizing the Composition of Molecular Motors on Moving Axonal Cargo Using "Cargo Mapping" Analysis

Published on: October 30, 2014

Small molecule compound logistics outsourcing--going beyond the "thought experiment".

Devon L Ramsay1, Joseph D Kwasnoski, Gary W Caldwell

  • 1Community of Research Excellence & Advanced Technology (CREATe), Janssen Pharmaceutical Companies of Johnson and Johnson, Welsh and McKean Roads, Spring House, PA 19477-0776, USA. dramsay1@its.jnj.com

Current Topics in Medicinal Chemistry
|May 11, 2012
PubMed
Summary

Johnson & Johnson Pharmaceutical Research & Development (J PRD) successfully outsourced its compound inventory and processing to a third party, achieving cost savings and improved service. Sustainable success requires dedicated vendor management and transparent IT infrastructure.

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Area of Science:

  • Pharmaceutical industry
  • Drug discovery
  • Outsourcing strategies

Background:

  • Increasing cost pressures drive pharmaceutical companies to outsource drug discovery.
  • Compound collections are critical assets in drug discovery.
  • Johnson & Johnson Pharmaceutical Research & Development (J PRD) initiated a significant outsourcing of its compound management.

Purpose of the Study:

  • To discuss the implementation of a hybrid model for compound management.
  • To share lessons learned from outsourcing compound inventory and processing.
  • To evaluate the impact of outsourcing on cost, service, and flexibility.

Main Methods:

  • Implemented a combination model: local compound logistics site support with an outsourced centralized processing center.
  • Managed external third-party vendor for compound inventory and processing.
  • Monitored service response, cost savings, and business adaptability over five years.

Main Results:

  • Achieved substantial cost savings.
  • Improved local service response times.
  • Established a flexible platform adaptable to changing business needs.

Conclusions:

  • Outsourcing compound management can yield significant benefits.
  • Sustainable success depends on dedicated vendor management, collaborative approach, and robust IT infrastructure with transparency.
  • Key lessons learned from the outsourcing experience were both predictable and unexpected.