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Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...

Drug Administration and Therapy Phases: Overview

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
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Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

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An integrated data management framework for drug discovery--from data capturing to decision support.

Walter Cedeño¹, Simson Alex, Edward P Jaeger

¹Janssen Research & Development, Johnson & Johnson, Welsh and McKean Roads, Spring House, PA 19477, USA. wcedeno@its.jnj.com

Current Topics in Medicinal Chemistry

|May 11, 2012

Summary

Johnson & Johnson developed the Advanced Biological and Chemical Discovery (ABCD) platform to streamline drug discovery data management. This integrated software enhances data sharing and analysis for improved drug efficacy and safety.

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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Published on: December 11, 2016

Area of Science:

Pharmaceutical Sciences
Computational Chemistry
Bioinformatics

Background:

Drug discovery involves complex, multidisciplinary collaboration and data integration.
Existing information management systems struggle with the complexity and volume of scientific data.
Seamless data exchange and meaningful integration are crucial for optimizing drug efficacy and safety.

Purpose of the Study:

To describe the Advanced Biological and Chemical Discovery (ABCD) software platform.
To present a unified framework for collecting, annotating, organizing, integrating, mining, and visualizing drug discovery data.
To offer a consistent, extensible, and user-friendly solution for pharmaceutical research.

Main Methods:

Development of the Advanced Biological and Chemical Discovery (ABCD) software platform.
Implementation of operational subsystems for managing reagents, reactions, compounds, and assays.
Integration of advanced data mining and visualization tools for Structure-Activity Relationship (SAR) analysis.
Delivery of capabilities through the Third Dimension Explorer (3DX) common application front-end.

Main Results:

The ABCD platform provides coherence in drug discovery data management.
Key components include operational subsystems and advanced data analysis tools.
The Third Dimension Explorer (3DX) offers a modular, multifunctional, and extensible user interface.

Conclusions:

The ABCD platform offers a robust and integrated solution for pharmaceutical data management.
It addresses the need for streamlined data exchange and analysis in drug discovery.
The platform aims to improve the efficiency and effectiveness of developing new drugs.