Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corticosteroids and the brain.

E R de Kloet1, J M Reul, W Sutanto

  • 1Department of Neuroendocrine Pharmacology, University of Leiden, The Netherlands.

The Journal of Steroid Biochemistry and Molecular Biology
|November 20, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Science with Seymour Levine: on glucocorticoid action from birth to senescence.

Neurobiology of stress·2026
Same author

Effects of the mineralocorticoid receptor antagonist eplerenone in experimental autoimmune encephalomyelitis.

The Journal of steroid biochemistry and molecular biology·2024
Same author

Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation.

Frontiers in neuroendocrinology·2018
Same author

Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats.

Journal of neuroendocrinology·2017
Same author

Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism.

Neural plasticity·2016
Same author

Isoform switching of steroid receptor co-activator-1 attenuates glucocorticoid-induced anxiogenic amygdala CRH expression.

Molecular psychiatry·2016
Same journal

The Microbiome-Gut-Gonad Axis: How Microbial Metabolites Orchestrate Reproductive Physiology, Pathology, and Therapy.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

L-arginine improves prenatal and pre-pubertal codeine-induced steroidogenesis deregulation by suppressing oxidative stress-dependent signaling in male wistar rats.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

Discovery of 17-imidazo[1,2-a]pyridinyl-3α-hydroxy-5α-androstanes (17IPAs) as novel potent positive allosteric modulators of the GABA<sub>A</sub> receptor: Synthesis, in vitro and in silico studies.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

Androgen receptor as therapeutic indicator for LAR-positive triple-negative breast cancer: Preclinical and clinical assessment.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

The 24,25(OH)<sub>2</sub>D<sub>3</sub>-TLCD3B signaling complex and reproductive function in mice and men.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

Testosterone and epitestosterone differentially regulate UDP-glucuronosyltransferases (UGT) activity.

The Journal of steroid biochemistry and molecular biology·2026
See all related articles

Mineralocorticoid and glucocorticoid receptors in the brain are coordinately regulated and sensitive to early-life stress. These changes impact stress response and brain aging throughout life.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Molecular Biology

Background:

  • Mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) are crucial in the central nervous system, particularly within the limbic system.
  • These receptors play a key role in regulating mood, affect, and the hypothalamic-pituitary-adrenal (HPA) axis.

Purpose of the Study:

  • To investigate the expression, regulation, and developmental plasticity of MR and GR in the brain.
  • To understand the implications of MR and GR changes on stress response and brain aging.

Main Methods:

  • Radioligand binding studies
  • Autoradiography
  • Immunocytochemistry
  • In situ hybridization

Main Results:

Related Experiment Videos

  • MR and GR are abundant in hippocampal neurons, with MR binding corticosterone (CORT) and aldosterone (ALDO) with high affinity, while GR binds CORT with lower affinity.
  • MR and GR expression is coordinately regulated; changes in one receptor affect the other.
  • Early-life exposure to stressors or hormones permanently alters MR and GR ontogeny, with lasting effects into senescence.

Conclusions:

  • MR and GR exhibit differential ontogenetic patterns and are susceptible to permanent modification by early-life experiences.
  • Altered MR and GR levels due to early-life events can lead to long-term changes in CORT responsiveness, stress regulation, behavior, and brain aging.