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Neurosteroids: a new brain function?

E E Baulieu1, P Robel

  • 1Communications Hormonales (U33), INSERM, Bicêtre, France.

The Journal of Steroid Biochemistry and Molecular Biology
|November 20, 1990
PubMed
Summary
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Neurosteroids like pregnenolone and dehydroepiandrosterone are synthesized in the rat brain by oligodendrocytes. This brain synthesis pathway is independent of peripheral glands and influences neuronal function.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Cell Biology

Background:

  • Neurosteroids, including pregnenolone and dehydroepiandrosterone, are synthesized in the brain.
  • This synthesis occurs independently of peripheral endocrine glands.

Purpose of the Study:

  • To investigate the pathway of neurosteroid biosynthesis in the rat brain.
  • To identify the specific cells responsible for this synthesis.
  • To explore the proposed biological functions of neurosteroids.

Main Methods:

  • Enzyme immunocytochemistry in rat brain oligodendrocytes.
  • Conversion of radioactive precursors to C-21 steroids.

Main Results:

  • Discovery of a neurosteroid biosynthesis pathway in rat brain oligodendrocytes.

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  • Pregnenolone and dehydroepiandrosterone are synthesized within the brain.
  • These neurosteroids may act as precursors for other steroids and modulate neuronal activity.

    • Conclusions:

    • Oligodendrocytes possess a cholesterol-based pathway for synthesizing neurosteroids.
    • Neurosteroids play a role in brain function, potentially affecting behavior and neuronal excitability.
    • Further research is needed to understand the full physiological significance of neurosteroid synthesis in mammals.