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Related Experiment Videos

Changes in hepatic androgen sensitivity and gene expression during aging.

B Chatterjee1, A K Roy

  • 1Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.

The Journal of Steroid Biochemistry and Molecular Biology
|November 20, 1990
PubMed
Summary

Aging male rats lose liver androgen sensitivity, linked to cytoplasmic androgen binding (CAB) protein loss. Calorie restriction delays this, suggesting a molecular mechanism for liver andropause involving gene regulation.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Gerontology

Background:

  • Aging male rats show declining liver androgen responsiveness.
  • Calorie restriction extends lifespan and delays age-associated androgen insensitivity.
  • Androgen receptor mRNA and cytoplasmic androgen binding (CAB) protein correlate with liver androgen sensitivity.

Purpose of the Study:

  • Investigate the molecular basis of age-related androgen insensitivity in rat liver.
  • Explore the role of gene regulation in liver andropause.
  • Determine the impact of nutritional manipulation on hormone sensitivity.

Main Methods:

  • Studied differential gene expression of androgen-responsive markers: SMP-2 (repressed) and alpha 2u-globulin (induced).
  • Examined the correlation between hepatic androgen sensitivity, CAB protein activity, and androgen receptor mRNA.

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  • Investigated the role of nuclear transcription factors in regulating target genes during aging and calorie restriction.

    • Main Results:

    • Aging leads to loss of hepatic CAB activity and androgen insensitivity.
    • Androgen resistance in aging hepatocytes represses alpha 2u-globulin gene expression.
    • Androgen resistance in aging hepatocytes derepresses SMP-2 gene expression.

    Conclusions:

    • Age-related liver androgen insensitivity is associated with loss of CAB activity and altered gene expression.
    • Calorie restriction may modulate liver andropause through regulation of androgen-responsive genes.
    • Understanding these molecular mechanisms is crucial for addressing age-related hormonal changes in the liver.