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Serum ferritin-a novel risk factor in acute myocardial infarction

M P Holay1, A A Choudhary, S D Suryawanshi

  • 1Department of Medicine, Indira Gandhi Government Medical College, Nagpur, India. mpholay@rediffmail.com

Indian Heart Journal
|May 11, 2012
PubMed

Insights

High serum ferritin levels are strongly linked to acute myocardial infarction (AMI), independent of other risk factors. This finding highlights iron status as a significant predictor for heart attack risk.

Area of Science:

  • Cardiology
  • Biochemistry
  • Internal Medicine

Background:

  • The association between body iron status and coronary heart disease (CHD) risk remains controversial.
  • Existing studies present conflicting data regarding iron levels and heart disease incidence.

Purpose of the Study:

  • To investigate the relationship between serum ferritin levels and acute myocardial infarction (AMI).
  • To analyze this association using univariate and multivariate models.
  • To determine if high serum ferritin correlates with established cardiovascular risk factors.

Main Methods:

  • A hospital-based case-control study was conducted.
  • 75 AMI patients (cases) were compared with 75 age- and gender-matched controls.
  • Participants were aged between 30-70 years.

Main Results:

  • Median serum ferritin was significantly higher in AMI cases (220 μg/L) versus controls (155 μg/L) (P ≤ 0.0001).
  • Univariate analysis identified high ferritin (> 200 μg/L), diabetes, hypertension, low HDL, and smoking as significant AMI predictors.
  • Multivariate analysis confirmed high serum ferritin as an independent predictor of AMI (adjusted OR=5.72, P < 0.001).
  • Serum ferritin levels were also significantly higher in diabetic patients.

Conclusions:

  • Elevated serum ferritin is a strong and independent risk factor for acute myocardial infarction.
  • Iron status, indicated by serum ferritin, plays a crucial role in AMI development.
  • These findings suggest serum ferritin as a potential biomarker for cardiovascular risk assessment.
Abstract

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