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Updated: May 22, 2026

Isolation and Cellular Phenotyping of Mesenchymal Stem Cells Derived from Synovial Fluid and Bone Marrow of Minipigs
10:47

Isolation and Cellular Phenotyping of Mesenchymal Stem Cells Derived from Synovial Fluid and Bone Marrow of Minipigs

Published on: July 2, 2016

Pigmented villonodular synovitis therapy with MSCF-1 inhibitors

H Thomas Temple1

  • 1Department of Orthopaedic Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. htemple@med.miami.edu

Current Opinion in Oncology
|May 11, 2012
PubMed
Abstract

Insights

Imatinib shows promise for treating giant cell tumors and pigmented villonodular synovitis. This targeted therapy may stabilize aggressive or recurrent synovial-based tumors, offering a new treatment avenue.

Area of Science:

  • Oncology
  • Orthopedics
  • Pharmacology

Background:

  • Giant cell tumor of tendon sheath (GCT-TS) and pigmented villonodular synovitis (PVNS) are neoplastic conditions originating from the synovium.
  • Current standard treatment involves surgical excision, but recurrence and aggressive disease necessitate alternative therapeutic strategies.

Purpose of the Study:

  • To review the potential of targeted therapy for GCT-TS and PVNS.
  • To explore imatinib as a treatment option for aggressive and recurrent cases.

Main Methods:

  • Literature review focusing on targeted therapies for GCT-TS and PVNS.
  • Analysis of existing clinical data on imatinib efficacy and safety.

Main Results:

  • Imatinib, a tyrosine kinase inhibitor, targets colony-stimulating factor 1 (CSF1) production by tumor cells.
  • Clinical data suggest imatinib can stabilize disease in most patients with manageable side effects.
  • A subpopulation of tumor cells recruits nonneoplastic cells expressing CSF1.

Conclusions:

  • Imatinib represents a promising targeted therapy for GCT-TS and PVNS.
  • Other CSF1R inhibitors and monoclonal antibodies may also play a significant role in managing these tumors.

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