Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Histologic Entry Criteria for Clinical Trials in Celiac Disease Involving Gluten Challenge.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Celiac Disease.

The New England journal of medicine·2026
Same author

Small intestinal microbial fiber metabolism dysfunction in celiac disease.

Nature communications·2026
Same author

Evaluating the Clinical Relevance of Elevated Mucosal Mast Cells in the Gastrointestinal Tract.

Journal of clinical gastroenterology·2025
Same author

Drugs in Development and Clinical Trials for Celiac Disease.

Gastrointestinal endoscopy clinics of North America·2025
Same author

Immunology in Celiac Disease.

Gastrointestinal endoscopy clinics of North America·2025

Related Experiment Video

Updated: May 22, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Animal models to study gluten sensitivity.

Eric V Marietta1, Joseph A Murray

  • 1Department of Immunology, Mayo Clinic, Rochester, MN, USA.

Seminars in Immunopathology
|May 11, 2012
PubMed
Summary
This summary is machine-generated.

Developing and maintaining tolerance to dietary antigens like gluten is vital. Failures in this process can lead to diseases such as celiac disease (CD) and dermatitis herpetiformis (DH), highlighting the importance of understanding these immune responses.

More Related Videos

Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component
07:39

Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component

Published on: September 1, 2023

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: May 22, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component
07:39

Basic Three-Dimensional (3D) Intestinal Model System with an Immune Component

Published on: September 1, 2023

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Immunology
  • Gastroenterology
  • Dermatology

Background:

  • Tolerance to dietary antigens is crucial for health; its failure leads to diseases like celiac disease (CD) and dermatitis herpetiformis (DH).
  • CD and DH are gluten-sensitive autoimmune disorders linked to specific HLA class II genotypes (DQ2/DQ8), yet only a fraction of carriers develop disease.
  • The varied age of onset suggests gluten intolerance may stem from a failure to develop tolerance or a loss of previously established tolerance.

Purpose of the Study:

  • To explore the mechanisms underlying the development and maintenance of tolerance to dietary antigens, particularly gluten.
  • To understand the pathogenesis of gluten-related disorders, including celiac disease, dermatitis herpetiformis, and non-celiac gluten sensitivity.
  • To review the contribution of animal models to elucidating gluten intolerance and associated diseases.

Main Methods:

  • Review of existing literature on dietary antigen tolerance and gluten-sensitive disorders.
  • Analysis of genetic predispositions, specifically HLA class II molecules DQ2 and DQ8.
  • Examination of insights gained from animal models of gluten-sensitive conditions.

Main Results:

  • Gluten intolerance, manifesting as CD, DH, or non-celiac gluten sensitivity, results from a breakdown in immune tolerance.
  • Specific genetic factors (HLA DQ2/DQ8) increase risk, but do not guarantee disease development, indicating complex environmental or developmental influences.
  • Animal models have proven instrumental in dissecting the immunological pathways involved in gluten sensitivity.

Conclusions:

  • Understanding the immunological mechanisms of gluten tolerance is key to preventing and treating related diseases.
  • Further research into non-celiac gluten sensitivity is needed to elucidate its underlying mechanisms.
  • Animal models provide valuable platforms for studying gluten intolerance and developing therapeutic strategies.