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Upper gastrointestinal bleeding in children: an 11-year retrospective endoscopic investigation
Katherine Cleveland1, Naveed Ahmad, Phyllis Bishop
1Division of Pediatric Gastroenterology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Insights
Improved endoscopic optics have not enhanced diagnosis for upper gastrointestinal bleeding (UGIB) in children. Timing of endoscopy and bleeding duration influence finding the source, with geographic variations in causes.
Area of Science:
- Pediatric Gastroenterology
- Endoscopic Diagnostics
- Gastrointestinal Bleeding
Background:
- Upper gastrointestinal bleeding (UGIB) presents variedly and requires esophagogastroduodenoscopy (EGD).
- Etiology of UGIB differs globally due to regional disease prevalence.
- Endoscopic technology has advanced, prompting re-evaluation of diagnostic efficacy.
Purpose of the Study:
- Assess if improved endoscopic optics enhance UGIB source identification in children.
- Investigate geographic variations in UGIB causes.
- Analyze UGIB severity based on clinical factors.
- Determine factors influencing the likelihood of finding a bleeding source, including symptom duration and time to endoscopy.
Main Methods:
- Retrospective chart review of pediatric patients undergoing EGD for UGIB.
- Data collection focused on bleeding type, etiology, and severity.
Main Results:
- UGIB accounted for 6.5% of EGD procedures (167/2569).
- Hematemesis was the most common presentation (73.4%); melena correlated with lower hemoglobin and higher transfusion needs.
- A bleeding source was identified in 57.0% of cases. Source identification was less frequent with shorter bleeding history (<1 month) and delayed endoscopy (>48 hours).
Conclusions:
- Enhanced endoscopic optics have not improved diagnostic success rates for pediatric UGIB.
- Geographic variations in UGIB etiology are influenced by endoscopy indications, patient selection, and comorbidities.
- Bleeding duration and time to endoscopy are critical factors for predicting successful source identification.
Background:
Upper gastrointestinal bleeding (UGIB) may present as hematemesis, coffee-ground emesis, or melena requiring esophagogastroduodenoscopy (EGD) for diagnosis and/or therapy. Worldwide, differences exist for the etiology of UGIB reflecting geographical differences in common disease states. In the past 25 years, there have been improvements in endoscopic optics. This study was undertaken to determine: 1) if identifying a bleeding source in UGIB have improved with better endoscopic optics, 2) geographic differences in causes of UGIB, 3) differences in severity of UGIB based on clinical factors, and 4) the likelihood of finding a bleeding source based on symptom duration and time to endoscopy.
Methods:
A retrospective chart review was made on children having EGD for evaluation of UGIB. Data collected included type, etiology, and degree of bleeding.
Results:
Of 2569 diagnostic procedures, 167 (6.5%) were performed for UGIB. The most common presentation was hematemesis (73.4%). Melena was associated with lower hemoglobin levels and higher transfusion rates. A source of UGIB was found in 57.0%, no cause in 11.4% and a questionable cause in 29.7%. A source was found less commonly in children with a history of UGIB less than one month and in those undergoing endoscopy over 48 hours after a bleeding episode.
Conclusions:
Improved endoscopic optics has not changed diagnostic ability for UGIB. Etiologic differences for UGIB in children from varying geographic areas are related to indication for endoscopy, patient selection, and co-morbid conditions. Duration of bleeding and time to endoscopy after a bleeding episode may help predict when endoscopy should be performed to determine a bleeding source.
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