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Updated: May 22, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
Published on: January 24, 2020
Considerations in the design of clinical trials for cognitive aging
Eric M Reiman1, Roberta Diaz Brinton, Russell Katz
1Banner Alzheimer's Institute, Banner Research, Translational Genomics Research Institute, University of Arizona College of Medicine, and Arizona Alzheimer's Consortium, Phoenix AZ 85006, USA. eric.reiman@bannerhealth.com.
Abstract:
What will it take to develop interventions for the treatment of age-related cognitive decline? Session V of the Summit provided perspectives on the design of clinical trials to evaluate promising but unproven interventions, and some of the steps needed to accelerate the discovery and evaluation of promising treatments. It considered strategies to further characterize the biological and cognitive changes associated with normal aging and their translation into the development of new treatments. It provided regulatory, scientific, and clinical perspectives about neurocognitive aging treatments, their potential benefits and risks, and the strategies and endpoints needed to evaluate them in the most rapid, rigorous, and clinically meaningful way. It considered lessons learned from the study of Alzheimer's disease, the promising roles of biomarkers in neurocognitive aging research, and ways to help galvanize the scientific study and treatment of neurocognitive aging.
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