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Related Experiment Video

Updated: May 22, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Low dose rapamycin exacerbates autoimmune experimental uveitis.

Zili Zhang¹, Xiumei Wu, Jie Duan

¹Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, United States of America. zhangzi@ohsu.edu

|May 11, 2012

Summary

Low dose rapamycin worsened experimental autoimmune uveitis (EAU) in mice by increasing antigen-reactive T cells. High doses of rapamycin, however, reduced ocular inflammation, revealing a dose-dependent effect.

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Area of Science:

Immunology
Ophthalmology

Background:

Rapamycin modulates the immune system, used for transplant rejection and autoimmune diseases.
Uveitis is a severe eye inflammation; rapamycin is being tested in clinical trials.
Low-dose rapamycin may enhance memory T cells, but its effect on uveitis is unknown.

Purpose of the Study:

To investigate the dose-dependent effects of rapamycin on experimental autoimmune uveitis (EAU).
To determine how rapamycin influences T cell responses and ocular inflammation in EAU.

Main Methods:

Experimental autoimmune uveitis (EAU) was induced in B10.RIII mice.
Mice were treated with low or high doses of rapamycin.
Ocular inflammation, splenocyte responses, and T cell activation-induced cell death (AICD) were assessed.

Main Results:

Low-dose rapamycin exacerbated EAU, increasing antigen-reactive lymphocytes.
High-dose rapamycin attenuated ocular inflammation.
Rapamycin-treated T cells showed reduced AICD, potentially contributing to inflammation.

Conclusions:

Rapamycin exhibits a paradoxical, dose-dependent role in uveitis.
Clinical use of rapamycin for uveitis may have unintended consequences based on dosage.
Further research is needed to elucidate the mechanisms of low-dose rapamycin's immune-augmenting effects.