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Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System
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Rapid and Specific Detection of Acinetobacter baumannii Infections Using a Recombinase Polymerase Amplification/Cas12a-based System

Published on: April 25, 2025

Acinetobacter baumannii nosocomial pneumonia in tertiary care hospitals in Thailand

Peerawong Werarak1, Jirachai Waiwarawut, Prasit Tharavichitkul

  • 1Siriraj Hospital, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|May 12, 2012
PubMed
Abstract

Insights

Acinetobacter baumannii is the leading cause of nosocomial pneumonia (NP) in Thailand, often exhibiting multi-drug resistance. This highlights the urgent need for effective treatment strategies for A. baumannii NP.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Nosocomial pneumonia (NP) significantly contributes to patient morbidity and mortality.
  • Acinetobacter baumannii is a prevalent pathogen in NP, with increasing rates of multi-drug resistance.
  • Limited data exists on the clinical characteristics and outcomes of A. baumannii NP in Thailand.

Purpose of the Study:

  • To investigate the clinical features, risk factors, and clinical courses of A. baumannii NP.
  • To provide insights into A. baumannii NP in Thai patients within tertiary care settings.

Main Methods:

  • Prospective, hospital-based active surveillance study.
  • Involved 651 patients with hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP).
  • Conducted across 12 tertiary care hospitals in Thailand from 2008 to 2009.

Main Results:

  • A. baumannii was the most frequent cause of NP (30.4%).
  • A. baumannii NP patients showed less favorable initial responses and higher mortality rates.
  • Multi-drug resistant A. baumannii isolates, including carbapenem resistance, were common.
  • Ventilator-associated pneumonia (VAP), ICU-acquired pneumonia, and bilateral lung involvement were associated with A. baumannii.

Conclusions:

  • A. baumannii is the predominant pathogen in Thai tertiary care NP, frequently resistant to antibiotics.
  • Patients with VAP, ICU-acquired pneumonia, or bilateral lung involvement are more likely to have A. baumannii NP.
  • Inappropriate initial antibiotic regimens contributed to high mortality rates in NP patients.

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