Related Experiment Video
Updated: May 22, 2026
Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
[Analysis on sero-conversion status of HIV-discordant spouse from 2006-2010 in Henan province]
Jie Li1, Yan-min Ma, Ding-yong Sun
1Institute for Prevention and Control of STD and AIDS, Henan Provincial Center for Diseases Control and Prevention, Zhengzhou 450016, China.
Insights
Management of HIV-discordant couples in Henan province shows a stable population and increasing testing acceptance. Consistent condom use is high, contributing to a low sero-conversion rate in HIV-discordant spouses.
Area of Science:
- Public Health
- Epidemiology
- Infectious Disease Management
Context:
- HIV-discordant couples represent a significant population within HIV/AIDS management.
- Understanding transmission dynamics and management strategies is crucial for effective public health interventions.
- Henan province, China, has been monitoring HIV-discordant families since 2006.
Purpose:
- To evaluate the management status and trends of HIV-discordant families in Henan province.
- To analyze sero-conversion rates and related factors within this population.
- To assess the effectiveness of current HIV prevention and management strategies.
Summary:
- The study analyzed data from 2006-2010 on HIV-discordant families in Henan province.
- Sero-conversion rates among HIV-discordant spouses showed a decreasing trend annually.
- Consistent condom use was reported by most couples, correlating with a low overall sero-conversion rate.
Impact:
- Findings indicate a stable HIV-discordant population with improving management outcomes.
- Increased testing acceptance and prolonged sero-conversion intervals suggest successful intervention strategies.
- The study provides valuable insights for public health policy and HIV/AIDS control programs in similar settings.
Objective:
To study the management status of HIV-discordant family in Henan province from 2006 to 2010.
Methods:
Data on AIDS infected family from "AIDS Infected Family Follow-up Management and Analysis System" was collected and analyzed to understand the management status of HIV-discordant situation.
Results:
The sero-conversion rates of HIV-discordant spouse were 1.94/100 person-years in 2006, 1.79/100 person-years in 2007, 0.59/100 person-years in 2008 and 0.41/100 person-years in 2009, showing the yearly decrease. Regarding the number of sero-conversion in the same year, male was significantly higher than female in 2007, but not in the other years. The ratio on the course of sero-conversion which was > 2.5 years was increasing. Frequency of most HIV-discordant couples' sexual activities was 1-4 times/month with consistent use of condoms.
Conclusion:
The population of HIV-discordant spouse in Henan province was stable. Regarding management of those HIV-discordant spouse, the acceptance on the rate of test rate was increasing. The course of sero-conversion was also increasing, with most HIV-discordant couples insist on condom use while the sero-conversion rate of HIV-discordant spouse appeared to be low.
