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Published on: March 7, 2017
Pericytoma with t(7;12) and ACTB-GLI1 fusion arising in bone
Julia A Bridge1, Kyle Sanders, Dali Huang
1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA. jbridge@unmc.edu
Abstract:
Cytogenetic analysis of a primary bone neoplasm with pericytic features in a 67-year-old man revealed a t(7;12)(p22;q13) among other karyotypic abnormalities. Subsequent molecular studies confirmed the presence of an associated ACTB-GLI1 fusion transcript. An identical 7;12 translocation is known to characterize a discrete group of soft tissue tumors belonging to the myopericytic category termed pericytoma with t(7;12). To the best of our knowledge, this is the first case of pericytoma with t(7;12) arising in bone. Cytogenetic and molecular analyses were useful, if not essential, in classifying this rare diagnostic entity.
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