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Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Oral Hypoglycemic Agents: Biguanides and Glitazones01:26

Oral Hypoglycemic Agents: Biguanides and Glitazones

Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood glucose levels...
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...

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The ADIPS Pilot National Diabetes in Pregnancy Benchmarking Programme.

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Related Experiment Video

Updated: May 22, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Insulin therapy in pregnancy.

Aidan McElduff1, Robert G Moses

  • 1Discipline of Medicine, Sydney University, Sydney, NSW, Australia. aidanm@med.usyd.edu.au

Endocrinology and Metabolism Clinics of North America
|May 12, 2012
PubMed
Summary

Insulin therapy is crucial for managing diabetes during pregnancy. While used for type 1 and type 2 diabetes, gestational diabetes mellitus (GDM) is the most common reason for insulin use in pregnant individuals.

Area of Science:

  • Obstetrics
  • Endocrinology
  • Pharmacology

Background:

  • Insulin therapy is vital for glycemic control in pregnant women with type 1 diabetes.
  • It is also frequently needed for type 2 diabetes and gestational diabetes mellitus (GDM).
  • GDM is the most prevalent reason for insulin use during pregnancy due to its higher incidence.

Purpose of the Study:

  • To review the role and common regimens of insulin therapy in managing diabetes during pregnancy.
  • To highlight the prevalence of insulin use across different types of diabetes in pregnancy.

Main Methods:

  • Review of current literature and clinical practice regarding insulin use in pregnancy.
  • Analysis of common insulin regimens, including basal/bolus strategies.

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An In Ovo Model for Testing Insulin-mimetic Compounds
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An In Ovo Model for Testing Insulin-mimetic Compounds

Published on: April 23, 2018

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Last Updated: May 22, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

An In Ovo Model for Testing Insulin-mimetic Compounds
06:09

An In Ovo Model for Testing Insulin-mimetic Compounds

Published on: April 23, 2018

Main Results:

  • The basal/bolus combination of long- and short-acting insulin is the most frequent regimen used.
  • No specific evidence supports one regimen over another.
  • Gestational diabetes mellitus accounts for the majority of insulin use in pregnancy.

Conclusions:

  • Insulin therapy is indispensable for achieving optimal glycemic control in pregnant women with diabetes.
  • Individualized treatment approaches are recommended.
  • Therapeutic decisions should be guided by local expertise and patient-specific factors.