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Radioimmunoguided surgery in primary colon cancer
C A Nieroda1, C Mojzisik, A Sardi
1National Institutes of Health, National Cancer Institute, Bethesda, MD 20892.
Cancer Detection and Prevention
|January 1, 1990
Summary
Radioimmunoguided surgery (RIGS) uses a gamma detecting probe (GDP) to detect radiolabeled antibodies, improving tumor margin definition and identifying occult metastases in colon cancer patients. This technique aids intraoperative staging, potentially reducing recurrence and improving survival rates.
Area of Science:
- Surgical Oncology
- Nuclear Medicine
- Immunotherapy
Background:
- Primary colon carcinoma presents challenges in complete tumor resection and staging.
- Accurate intraoperative assessment of tumor margins and metastatic spread is crucial for effective treatment.
Purpose of the Study:
- To evaluate the efficacy of Radioimmunoguided Surgery (RIGS) in primary colon carcinoma.
- To assess the ability of a gamma detecting probe (GDP) to identify tumor tissue and metastatic sites intraoperatively.
Main Methods:
- 30 patients with primary colon carcinoma received MAb B72.3 radiolabeled with 125I.
- A hand-held gamma detecting probe (GDP) was used intraoperatively to measure radioactivity in various tissues.
- Radioactivity measurements were correlated with histological findings.
Main Results:
- Antibody localization to tumor was confirmed in 77% of patients.
- Tumor margins were more clearly defined in 67% of cases.
- RIGS identified occult metastases (liver and nodal) in 7-13% of patients and altered surgical/adjuvant therapy in 14-17%.
Conclusions:
- RIGS precisely delineates tumor margins and nodal involvement.
- The technique effectively localizes occult tumor, aiding immediate intraoperative staging.
- RIGS may lead to reduced recurrence rates and improved survival in colon cancer patients.